My adventure in life began in the kitchen I was fascinated with food, at an early age, but did not realize how it would ultimately affect my life, until I finished my pharmacy degree.
It was upon my mother’s insistence that I develop a skin cream that would treat her dishpan-ravaged hands.
Being the smart fresh graduate, I simply put together all different products to provide her with a poly preparation approach. This was met with scorn and abuse, and quite frankly she was not interested, she wanted a fresh approach, one that would ensure the natural regeneration of the skin to its normal healthy state.
The challenge was to create a topical preparation preferably a cream incorporating fresh avian egg. It seemed that my German grandmother, an experienced hair dresser, had such a formula that not only regenerated skin, but hair as well. Unfortunately my grandmother was deceased and her formula went with her.
I could only rely upon my intuition and powers of observation to create this extraordinary product.
After two years of experimentation, a product called HEALFAS was born, simply put it was a combination of fresh avian egg, nut oils, sugars and essential fatty acids in a specially designed base that allowed complete expression of all of its ingredients, especially the foods which were the active ingredients that breathed life into an otherwise DEAD formula.
The final product was in essence a food, and with all of its qualities the name HEALFAS was derived from combining English and Latin, Heal from English and Fas from Latin, the latter meaning natural laws pertaining to, healing in this case, but not forced or influenced Healing but Natural Healing, and so, the letters N.M.F. were added, these stood for natural, mending factors.
Healfas NMF a natural source of regeneration.
At last my mother was happy however I did not realize how joyful I had made her. Being a very curious woman she experimented with the product on all sorts of “accidents”, cuts, abrasions, burns, wrinkles, fingernail growth, various infections, hair conditioning etc. and found it to be absolutely brilliant.
I dismissed all of these claims, because I considered them nothing more than the ramblings of a very proud and supportive mother.
Some years later I found myself in business in a Coastal town called Yanchep some 60 minutes by car, north of Perth, famous for its crayfish fishing industry and the Atlantis Marine Park.
Once again at the insistence of my mother, I designed a simple label for the product and started to sell it from my pharmacy.
The locals embraced the product warmly, and the glowing unsolicited testimonials flowed freely.
Stories of the resolution of dermatitis, eczema, psoriasis, nappy rash, cold sores, shingles, diabetic ulcers, burns (to about partial 2nd degree), sunburn, accelerated fingernail growth, accelerated hair growth in women and animals (dogs, horses, cats), and even control of certain skin cancers, were delivered on a weekly if not daily basis.
The Sunday Times newspaper, ran a small article on the discovery and a local TV station also broadcast a segment on one of its current affair programs.
I could no longer act as the bumbling absent-minded inventor I had to make an effort to understand what I had discovered but I already knew that:
- The product supplied complete topical nutrition.
- The product penetrated to deeper tissues, this being deduced by its ability to stimulate hair and nail growth and also reverse rheumatoid arthritis in the hands of one elderly male.
- The product interacted with normal skin physiology and possessed a unique carrier mechanism.
All of the above were supported by anecdotal evidence and the simple experiments I performed on myself and willing family members, for example, I incorporated several different blood lowering drugs into Healfas NMF applied the final product to the inside of my arm and watched my blood pressure fall quite dramatically which was unrelated to resting. One test that I did not like very much was when I applied Insulin incorporated into Healfas NMF and measured my blood sugar level, I became hypoglycemic within the hour with symptoms that included tachycardia, hyperventilation, pallor and a feeling of being sick, Six ice creams later and a little honey and I was better, however I still felt the after effects the following day. Strange that pharmaceutical companies and research Universities spend millions of dollars investigating novel delivery systems and yet the answer has been sitting under their noses all along all that was needed was for someone to put the jigsaw puzzle pieces together.
Besides the above it was my duty to come up with the correct explanations, especially in the light that the formulation accelerated regeneration and prevented scar tissue formulation.
The influence that nutrition has on wound healing was brilliantly dealt with in articles presented and written by Bruno (1979) and Schuman (1979) during a symposium on wound healing.
They both shared the idea that malnourished patients and their bodily tissues were neither immune-competent nor hormonal competent. Wound healing progressed very slowly, incompletely and resulted in abnormal regeneration with greater than normal scar tissue formation.
The approach that they took to remedy this situation was via the systemic route of delivering all essential nutrients. The topical application of nutrients to dermal injuries was never considered. Idson found that it was possible to achieve higher local concentrations of vitamins in the skin by topical application than by oral dosage. This included vitamins A, D2, E and panthenol.
As a consequence skin conditions such as Keratosis, Ichthyosis, Wrinkles, Connective tissue loss, Stretch marks, would benefit from the topical application of these substances
It was further found that essential fatty acids, protein hydrolysates also had a beneficial influence on skin physiology and traumatized states such as, Eczema, Psoriasis, Dermatitis. However penetration of the skin was limited by molecular size and other physiochemical properties. (, Johnsen & Chiostri 1978, Johnsen 1984, Prottey 1977, Takehara 1983)
The problems with all of these approaches was that people were dealing with chemically altered substances rather than with natural unaltered raw ingredients and that in the majority the research was performed by companies seeking profits rather than honest long lasting benefits for the consumers.
There were no commercially available products that considered satisfying the complete nutritional requirements of the skin before HEALFAS NMF even now this is still the case.
Centuries ago European peasants did use certain food combinations for topical use, but these had a very short shelf life, due to lack of preservatives.
The Healfas formula supplies everything that the skin requires and more to remain healthy and capable of quick regeneration, with almost no lag time to commence regeneration and healing time reduced by as much as 50%.
The first signs that this was occurring is how quickly the inflammatory phase subsided after application of the product. This is important for inflammation is the first step in the healing process and usually lasts 3 to 4 days. Ref (c)
The purpose of inflammation is to elicit cellular migration, blood flow and nutrition to the area. The healing process is classified into 3 phases, Defensive, Reconstructive and Regenerative the last may take up to 2 years after the trauma has occurred.
The rapid reduction in inflammation is via a biofeedback mechanism, which says all building blocks necessary are present please cease supply.
Because the product is made from fresh dairy food and nut oils, it not only contains the entire spectrum of nutrients necessary for new life, but it also contains genetic material namely RNA and DNA, plus various hormones, enzymes, growth factors and cholesterol.
Each of these contribute in a beneficial way to the healing process, cholesterol deserves more mention as do sulfur containing amino acids.
Cholesterol although much maligned for its “dirty role” in “causing“cardiovascular disease is in reality, a very beneficial natural substance.
It is only man’s skeptical and destructive attitudes that prevent a proper understanding of its importance.
Cholesterol was discovered in 1770 in gallstones by Poulletier de La Salle. Since then it has been identified in practically all living organisms, animal and vegetable and microscopic. It is present in bacteria, blue green algae, and fungi, human skin and sebum are rich in cholesterol.
It has been found in the Gulf of Mexico sea water and it is hypothesized that the formation of various compounds found in crude petroleum are from cholesterol.
Commercial sources include lanolin alcoholics (which explains why wool workers have beautiful skin on their hands and forearms through such contact) animal fats, fish oils and spinal cords (nerve tissue is high in content and expectant woman should not reduce their cholesterol intake during pregnancy, as this may lead to imperfect nerve formation and dysfunction in the fetus).
In a human weighing 65 kilo there is approximately 210 grams of cholesterol, the largest single amount being in the skin. Cholesterol is an important physiological component of all cells. It is bound to the proteins of the external membranes, it is a necessary growth factor in cells, and it is a precursor to steroid hormones, in the adrenal, ovary, testes. It is present in fingernails and in the enamel of teeth and it increases the vitamin D3 content of the skin.
As an ingredient in topical products, it serves as a skin protectant and treatment of certain skin disorders by simply replenishing itself.
The incorporation of 1% of cholesterol into olive oil increases the absorption of olive oil by the skin cholesterol has been used in hair tonics to stimulate hair growth. This is also the case with white soft paraffin, which normally sits on the skin surface. By adding cholesterol its penetration is increased by 33%, and overcomes problems such as interference with surface cooling and inhibition of perspiration.
Cholesterol is an especially active compound that can eliminate polymerization of light and therefore possess sun filtering qualities and it also prevents an induced erythema of the skin.
Cholesterol is found in situ in the skin oily skins contain high concentrations of it. Exposure to the sun slows its formation; interference with its synthesis produces dryness and chapping of the skin.
The lipid film of normal skin dermis is derived from the epidermis and sebaceous glands.
A certain zone within the horny layer of the skin known as the “barrier” is said to be responsible for inhibiting diffusion of water. The power of this barrier to retain water is primarily due to lipids that contain up to 90% cholesterol.
The composition of human skin lipids changes from birth to puberty. Cholesterol concentration is low at 5 days of age, increasing to a maximum between 4 – 8 years of age, (one argues that at this time, the skin is at its most beautiful, and the between 10 –15-years it decreases to adult levels. In aged skin there is a dramatic drop in skin cholesterol content, it is also very low in balding men and women, in psoriasis, and very low levels are thought to be associated with skin cancer formation.
Cholesterol in combination with Lecithin, Linoleic Acid and Alcohol, it has been claimed, promotes the healing of Burns, stimulates Hair growth and inhibits the growth of Herpes Virus.
The dermal “barrier” also contains amino acids, but most of these are essential, that is they must be obtained from dietary sources as the body does not synthesize these. These include Phenylalanine, Valine, Threonine, Tryptophan, Isoleucine, methionine, Lysine and Leucine. In addition, Histidine and Arginine are required by children.
Arginine is required for proper repair in the physically traumatized adult. It is a hot item in the food supplement market place, for its appeal has been fueled by its ability to burn fat while building muscle. By virtue of its unique stimulating effect upon growth hormone which in turn influences the synthesis of proteins in mice and humans. Arginine has been found to stimulate the immune system and produce highly activated white cells, it has also demonstrated a significant anti tumors effect in laboratory animals.
Cysteine, methionine and taurine, all sulfur containing amino acids, inactivate free radicals thus protecting and preserving cells. In diets supplemented with these, the life span of the animal is increased, by the above mechanism and via a participation in DNA repair and anti-carcinogenic effect.
Cysteine in combination with pantothenic acid produced very positive effects on patients suffering with osteoarthritis and rheumatoid arthritis.
Applied topically cysteine increased the rate of quality healing by up to 50%, in conditions such as grazes, varicose ulcers, diabetic ulcers, burns, psoriasis, lichen simplex and also in the formation and maturation of collagen. Similar results are also seen from other sulfur containing amino acids.
Methionine and taurine are important regulators in various nervous and muscle systems, in terms of growth and maintenance.
The simple occlusion of the skin (this is putting some sort of impervious covering over it) not only raises the water content of the stratum corneum but also the rate of penetration of lypophilic (fat loving, water-hating) drugs. No reasonable explanation has been offered for this phenomenon.
Soaps and detergents, surfactants (shampoos) influence trans-dermal substance penetration by acting on the barrier found within the stratum corneum making it permeable to water and water solutes including themselves.
Hence when one looks at complex shampoo formulas not only is the consumer cleaning their hair and scalp but allowing the penetration of the constituents which to some people may prove harmful.
However it appears that a limitation may be the molecular weight of the substance. Molecular weights of about 500 seem to be the upper limit.
A second explanation for the contribution of surfactants to penetration is provided by Rieger (1988). They suggest that the adjuvant surfactant molecule modifies junctions between cells. By interacting with the junctions protein surface, it becomes less hydrophilic, the gaps enlarge with an associated increase in hydrophilic channels; this allows large MW molecules to proceed through.
The penetration enhances such as propylene glycol, glycerine, dimethyl sulphoxide, and ethanol (alcohol) also modify the nature of the stratum corneum membrane, even to a permanent extent.
Other biological factors benefit that skin hydration, also play a role in substance penetration and absorption; these include disease states both dermal and systemic, cutaneous blood flow, skin biochemistry and cutaneous bio-transformations.
By now the picture of how important food is to us is slowly developing. But the magic of it can only be obtained by marrying the correct foods together in order to obtain the very best results. This is precisely what had happened with my experimentation. What also happened is that it raised my conscious awareness of the relationship between food and humans beyond that of simply placing it down our gullets, because in our gullet is not in our body. And the human skin is not as impervious as I or anyone of us had previously thought.
The part of the body’s “inside” is really “outside” – the alimentary canal which leads from mouth to anus. (Dixon 1986)
The function of this long tube with its various specialized regions is to digest incoming food. Digestion being the process of breaking food down into simpler substances that can be assimilated as sources of energy and building materials for the body’s maintenance and growth.
But what if the food is already broken down and what if it is now topically applied, on the very outside. What can we expect to see? In the case of Healfas NMF, as all of the anecdotal evidence suggests the complete care of the body’s largest organ, namely the skin and all its appendages, namely hair, nails and associated glands, whether they are intact or damaged.
Why because in the process of preparing the product from fresh produce, the mechanical process of incorporating fresh eggs with the other ingredients, ruptures the membranes surrounding the yolk, leading to activation of its enzymes and breakdown of large molecules into smaller constituents, which are very readily assimilated.
But can we expect a deeper effect? The answer again is yes, the answer is very complex and may not be limited to that contained in the literature on cholesterol and its influence on skin penetration of various substances.
Because Healfas encouraged fingernail and hair growth, it was correct to assume that it was doing this at the deep germinal layers of the skin. Also because it had such a profound effect on rheumatoid arthritis, to the point that the gentleman concerned, Mr. Marshall, could do away with his medication and play the piano again, it therefore hinted that it possessed extraordinary qualities.
Besides the influence of complete nutrition and the presence of cholesterol, other answers lay in both the yolk and white of the egg. Both were used in leather manufacture to facilitate the penetration of lipids into animal hides. It was not only the lipids of the yolk that achieved this, but proteins in the white as well. The ability of the product was not limited to itself because of its effect on deeper tissues, I decided to investigate the trans-dermal carrier mechanism and see what it would transport. Over a short period of time I conducted experiments on myself and willing family members, using certain drugs in Healfas NMF, (such as insulin, and anti-hypertensive drugs). Both of these products when applied topically, each in their own separate application, that is to say when the anti-hypertensive combination caused a lowering in blood pressure, and the insulin combination dramatically lowered the blood sugar levels.
M. Rieger, J. Riviere and J. Faucer published a series of papers on skin penetration and the various factors that influence it. Penetration may proceed transcellularly, i.e. through cells, intercellularly, i.e. paracellularly or between cells or through so-called shunts, i.e. holes in the membrane such as sweat ducts and hairs.
Penetration of substances is somehow related to the ethanol/water distribution coefficient and to their ability to ‘escape’ from the vehicle into and ultimately through the stratum corneum membrane (the outer membrance of the skin). This type of passive diffusion is also dependent on the molecular weight or shape of the penetrant, and its polarity.
There exists a series of mysterious substances, emulsifiers, solubilizers and penetration enhancers that materially increase transmembrane diffusion. These include DMSO (dimethyl sulfoxide) ethylene diamine, propylene glycol and glycerine.
Hydration of the skin also plays a major role in the rate of penetrationas does the removal of the stratum corneum by techniques such as peeling agents, abrasion or blistering which results in enhanced compound penetration with a return to normal flux when the stratum corneum has regenerated.
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ACADEMIC QUALIFICATIONS
1974 Bachelor of Science (Pharmacology and Histology)
University of Western Australia
1978 Bachelor of Pharmacy
Curtin University of Technology
1980 Postgraduate Diploma in Clinical Pharmacy
Curtin University of Technology
PROFESSIONAL QUALIFICATIONS
1979 Registration as Pharmaceutical Chemist |